Ana Sampedro Selected Research

Acute Intermittent Porphyria (Porphyria, Acute)

12/2022	Recombinant porphobilinogen deaminase targeted to the liver corrects enzymopenia in a mouse model of acute intermittent porphyria.
3/2021	High Prevalence of Insulin Resistance in Asymptomatic Patients with Acute Intermittent Porphyria and Liver-Targeted Insulin as a Novel Therapeutic Approach.
11/2019	Computational disease model of phenobarbital-induced acute attacks in an acute intermittent porphyria mouse model.
12/2018	Systemic messenger RNA as an etiological treatment for acute intermittent porphyria.
11/2018	Bioengineered PBGD variant improves the therapeutic index of gene therapy vectors for acute intermittent porphyria.
1/2018	An Inducible Promoter Responsive to Different Porphyrinogenic Stimuli Improves Gene Therapy Vectors for Acute Intermittent Porphyria.
4/2016	Glucose metabolism during fasting is altered in experimental porphobilinogen deaminase deficiency.
9/2015	Vitamin D-binding protein as a biomarker of active disease in acute intermittent porphyria.
12/2013	Safety and liver transduction efficacy of rAAV5-cohPBGD in nonhuman primates: a potential therapy for acute intermittent porphyria.
7/2013	Helper-dependent adenoviral liver gene therapy protects against induced attacks and corrects protein folding stress in acute intermittent porphyria mice.

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Ana Sampedro Research Topics

Disease

14	Acute Intermittent Porphyria (Porphyria, Acute) 12/2022 - 03/2010
4	Porphyrias (Porphyria) 01/2018 - 07/2013
2	Inflammation (Inflammations) 09/2021 - 01/2019
2	Hypertension (High Blood Pressure) 09/2021 - 12/2018
2	Pain (Aches) 12/2018 - 02/2013
1	Variegate Porphyria (Protoporphyrinogen Oxidase Deficiency) 09/2021
1	Hyperinsulinism (Hyperinsulinemia) 03/2021
1	Insulin Resistance 03/2021
1	Mitochondrial Diseases (Mitochondrial Disease) 12/2018
1	Starvation 01/2018
1	Viremia 01/2014
1	Hepatocellular Carcinoma (Hepatoma) 01/2014
1	Infections 01/2014
1	Metabolic Diseases (Metabolic Disease) 07/2013
1	Hemorrhage 02/2013
1	Chronic Renal Insufficiency 01/2012
1	Renal Insufficiency (Renal Failure) 01/2012

Drug/Important Bio-Agent (IBA)

12	Hydroxymethylbilane Synthase (Porphobilinogen Deaminase)IBA 12/2022 - 03/2010
7	Heme (Haem)IBA 09/2021 - 01/2012
3	PorphyrinsIBA 03/2021 - 03/2010
2	EnzymesIBA 09/2021 - 12/2018
2	Glucose (Dextrose)FDA LinkGeneric 09/2021 - 04/2016
2	Messenger RNA (mRNA)IBA 09/2021 - 12/2018
2	Phenobarbital (Luminal)FDA Link 03/2021 - 11/2019
2	Aminolevulinic Acid (Levulan)FDA Link 11/2019 - 01/2018
1	Recombinant ProteinsIBA 12/2022
1	Rifampin (Rifampicin)FDA LinkGeneric 09/2021
1	Protoporphyrinogen Oxidase (Protox)IBA 09/2021
1	Hemin (Panhematin)FDA Link 09/2021
1	Insulin (Novolin)FDA Link 03/2021
1	Apolipoprotein A-I (Apolipoprotein A1)IBA 03/2021
1	Carbon Tetrachloride (Tetrachloromethane)IBA 01/2019
1	Toll-Like Receptors (Toll-Like Receptor)IBA 01/2019
1	Acetaminophen (Paracetamol)FDA LinkGeneric 01/2019
1	Pharmaceutical PreparationsIBA 01/2018
1	Estrogens (Estrogen)FDA Link 01/2018
1	Vitamin D-Binding ProteinIBA 09/2015
1	Biomarkers (Surrogate Marker)IBA 09/2015
1	Immunoglobulin M (IgM)IBA 01/2014
1	Naphazoline (All Clear)FDA LinkGeneric 02/2013
1	Lidocaine (Xylocaine)FDA LinkGeneric 02/2013
1	Tetracaine (Amethocaine)FDA LinkGeneric 02/2013
1	Tobramycin (Nebcin)FDA LinkGeneric 02/2013
1	Diclofenac (SR 38)FDA LinkGeneric 02/2013
1	PorphobilinogenIBA 01/2012
1	AcidsIBA 01/2012

Therapy/Procedure

2	Therapeutics 09/2021 - 12/2013
1	Liver Transplantation 09/2015
1	Intravenous Injections 07/2013
1	Intravitreal Injections 02/2013
1	Anesthesia 02/2013
1	Nephrectomy 01/2012
1	Bone Marrow Transplantation (Transplantation, Bone Marrow) 03/2010